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DNA Repair Protein APE1 Degrades Dysfunctional Abasic mRNA in Mitochondria Affecting Oxidative Phosphorylation
Institution:1. Department of Medicine, University of Udine, 33100 Udine, Italy;2. Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02-106 Warsaw, Poland;3. Faculty of Biology, Institute of Genetics and Biotechnology, University of Warsaw, Pawinskiego 5A, 02-106 Warsaw, Poland;4. Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany;5. Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Germany;6. Laboratory of Mitochondrial Biogenesis, Centre of New Technologies, University of Warsaw, 02-097 Warsaw, Poland;7. ReMedy International Research Agenda Unit, Centre of New Technologies, University of Warsaw, 02-097 Warsaw, Poland
Abstract:
Keywords:mitochondria  apurinic/apyrimidinic endonuclease 1  RNA processing  oxidative phosphorylation  AMA"}  {"#name":"keyword"  "$":{"id":"k0030"}  "$$":[{"#name":"text"  "_":"antimycin A  APE1"}  {"#name":"keyword"  "$":{"id":"k0040"}  "$$":[{"#name":"text"  "_":"apurinic/apyrimidinic endonuclease 1  BER"}  {"#name":"keyword"  "$":{"id":"k0050"}  "$$":[{"#name":"text"  "_":"base excision repair  BrU"}  {"#name":"keyword"  "$":{"id":"k0060"}  "$$":[{"#name":"text"  "_":"bromouridine  ECAR"}  {"#name":"keyword"  "$":{"id":"k0070"}  "$$":[{"#name":"text"  "_":"extracellular acidification rate  IMS"}  {"#name":"keyword"  "$":{"id":"k0080"}  "$$":[{"#name":"text"  "_":"intermembrane space  MCE"}  {"#name":"keyword"  "$":{"id":"k0090"}  "$$":[{"#name":"text"  "_":"mitochondrial extract  MIA"}  {"#name":"keyword"  "$":{"id":"k0100"}  "$$":[{"#name":"text"  "_":"mitochondrial IMS assembly  NLS"}  {"#name":"keyword"  "$":{"id":"k0110"}  "$$":[{"#name":"text"  "_":"nuclear localization sequence  MTS"}  {"#name":"keyword"  "$":{"id":"k0120"}  "$$":[{"#name":"text"  "_":"mitochondrial targeting signal  mtDNA"}  {"#name":"keyword"  "$":{"id":"k0130"}  "$$":[{"#name":"text"  "_":"mitochondrial DNA  mtRNA"}  {"#name":"keyword"  "$":{"id":"k0140"}  "$$":[{"#name":"text"  "_":"mitochondrial RNA  mt-mRNA"}  {"#name":"keyword"  "$":{"id":"k0150"}  "$$":[{"#name":"text"  "_":"mitochondrial messenger RNA  MRGs"}  {"#name":"keyword"  "$":{"id":"k0160"}  "$$":[{"#name":"text"  "_":"mitochondrial RNA granules  PLA"}  {"#name":"keyword"  "$":{"id":"k0170"}  "$$":[{"#name":"text"  "_":"proximity ligation assay  ROS"}  {"#name":"keyword"  "$":{"id":"k0180"}  "$$":[{"#name":"text"  "_":"reactive oxygen species  TCE"}  {"#name":"keyword"  "$":{"id":"k0190"}  "$$":[{"#name":"text"  "_":"total cell extract  4sU"}  {"#name":"keyword"  "$":{"id":"k0200"}  "$$":[{"#name":"text"  "_":"4-thiouridine
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