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The interferon landscape along the respiratory tract impacts the severity of COVID-19
Institution:1. Harvard Medical School, Boston Children’s Hospital, Division of Immunology, Boston, MA 02115, USA;2. Department of Biotechnology and Biosciences and Ph.D. Program in Molecular and Translational Medicine (DIMET), University of Milano - Bicocca, Milan 20100, Italy;3. Respiratory Disease Unit IRCCS San Matteo Hospital Foundation, Pavia 27100, Italy;4. Immunoregulation Laboratory, The Francis Crick Institute, London NW1 1AT, UK;5. Laboratory of Medical Microbiology and Virology, Vita-Salute San Raffaele University, Milan 20100, Italy;6. IRCCS San Raffaele Hospital, Milan 20100, Italy;7. Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, Los Angeles, CA, USA;8. Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, Milan 20100, Italy;9. Harvard Medical School, Boston Children’s Hospital, Division of Gastroenterology, Boston, MA 02115, USA;10. Institutional Centers for Clinical and Translational Research, Boston Children’s Hospital, Boston, MA 02115, USA;11. Department of Anesthesia and Critical Care Medicine, IRCCS Policlinico San Matteo Foundation, Pavia 27100, Italy;12. Division of Anesthesiology and Intensive Care, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, University of Milan, Milan 20100, Italy;13. Value-based healthcare unit, IRCCS Multimedica, Milan 20100, Italy;14. Department of Health Sciences, University of Milan, Milan 20100, Italy;15. Department of Internal Medicine and Pharmacology, University of Pavia, Pavia 27100, Italy
Abstract:
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  • Keywords:interferon  Type I IFN  Type III IFN  COVID-19  SARS-CoV-2  dendritic cell  epithelial cell  pattern recognition receptor  lung  airways
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