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Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment
Institution:1. Inflammatory Cell Dynamics Section, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA;2. Leidos Biomedical Research, Bethesda, MD 20892, USA;3. Kelly Government Solutions, Bethesda, MD 20892, USA;4. Molecular Targeting Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy;5. Microbiome and Genetics Core, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA;6. Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;7. Immunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA;8. Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;9. Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Abstract:
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  • Keywords:tumor microenvironment  microbiota  monocytes  dendritic cells  interferon  cancer immunology  macrophages  immune checkpoint blockade immunotherapy  STING  innate immunity
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