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A defective viral genome strategy elicits broad protective immunity against respiratory viruses
Affiliation:1. Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA;2. Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan;3. Department of Biology and Genetics, Stanford University, Stanford, CA 94305, USA;4. Baxter Laboratory for Stem Cell Biology, Department of Microbiology & Immunology, Stanford University, Stanford, CA 94305, USA;5. Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA;6. Aleph Therapeutics, Inc., Stanford, CA 94305, USA;7. School of Life Sciences, Jilin University, Changchun, China;8. Tauber Bioinformatics Research Center and Department of Evolutionary & Environmental Biology, University of Haifa, Mount Carmel, Haifa 31905, Israel;9. Pine Biotech Inc., New Orleans, LA 70112, USA;10. Functional Genomics and Cellular Engineering, AI and Cognitive Software, IBM Almaden Research Center, San Jose, CA 95120, USA
Abstract:
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  • Keywords:defective viral genomes  broad-spectrum  antiviral  innate immunity  interferon  RNA viruses  respiratory infection  SARS-CoV-2
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