大鼠杏仁中央核内注射CRH对血压的影响及其中枢机制初探

在戊巴比妥钠麻醉的大鼠，观察杏仁中央核内微量注射促肾上腺皮质激素释放激素对血压的影响，并对其中枢机制进行初步探讨。结果如下：（１）ＣｅＡ内微量注射ＣＲＨ产生剂量依赖血压升高，这种升压效应一般出现在 注射后５ｍｉｎ左右，可维持１ｈ以上。（２）ＣｅＡＣＲＨ体拮抗ａ－ｈｅｌｉｃａｌＣＲＨ９－４１，能取消ＣｅＡ内注射ＣＲＨ引起的升压效应。（３）侧脑室内给予纳洛酮，显著减弱ＣｅＡ内注射ＣＲＨ引起的升压效应。

EFFECT OF MICROINJECTION OF CRH INTO RAT CENTRAL NUCLEUS OF AMYGDALA ON BLOOD PRESSURE AND ITS CENTRAL MECHANSM

The effect of microinjection of corticotropin releasing hormone (CRH) into the central nucleus of amygdala (CeA) on blood pressure was examined in Wistar rats anaesthetized with pentobarbital sodium. The results were as follows: (1) Microinjection ofCRH 100, 500 ng into the CeA produced a dose-dependent increase in blood pressure.The response occurred 5 min after injection and lasted for at least 1 h. (2) The response could be blocked by injection of CRH receptor antugonist a-helical CRH9-41 intoCeA- (3) Lateral ventricle injection of naloxone could also attenuate the pressor response of CRH. (4) After injection of a-helical CRH9-41 into nucleus of solitary tract,the pressor response of CRH was diminished. The results suggest that the pressor effectinduced by microinjection of CRH into the CeA might be pertly mediated through opioidsystem via a descending pathway from CeA to NTS.