急性出血性结膜炎流行后居民中柯萨奇病毒A24变种抗体水平的变化

由柯萨奇病毒A24变种(CA24v)引起的急性出血性结膜炎(AHC)在沙市出现首次流行后半年与1年(即1989年春、秋季),从城市居民中采集了423份血清,用微量中和试验作了CA24v中和抗体与特异性IgM的检测。春季中和抗体阳性率为37.9％,特异性IgM阳性率为3.3％;秋季为48.8％与6.7％,并从感冒样病人中分离到1株CA24v,提示1989年秋季又有一次CA24v的传播过程。在年龄分布上,秋季中各年龄组抗体阳性率已无明显差异,提示经一年多的传播扩散,各年龄组的免疫水平已趋于接近,达到50％左右,并预测近期内本地将不会有CA24v引起的AHC流行。

Change of the Antibody Level among Inhabitants after the First Epidemic of AHC Caused by CA24v

Half and one year after the epidemic of acute hemorrhagic conjunctivitis(AHC) caused by eoxsackievirus A24 variant(CA24v) in the autumn of 1988, 423 sera were collected and the neutralization antibody(NA) and specific IgM against CA24v were tested in microplate with Hela cells. The positive rate of NA was 37.9% in the spring and 48.8% in the autumn of 1989. The specific IgM was 3.3% in the spring and 6.7% in the autumn of 1989 and one strain of CA24v was isolated from a cold-like patient at this time. The results suggest that a disseminating process caused by CA24v occurred again in the autumn. After the dissemination, the NA positive rate in all age groups was about 50% and no significant difference was found between age groups. Therefore, we forecast that there will not be epidemic of AHC due to CA24v in the near future.