Seroprevalence of Toxoplasma gondii assayed using Rapid Diagnostic Tests among Residents in Three Counties Adjacent to The Demilitarized Zone,Korea |
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Authors: | Jeehi Jung Jinyoung Lee Yoon Kyung Chang Seong Kyu Ahn Seo Hye Park Sung-Jong Hong Jihoo Lee Chom-Kyu Chong Hye-Jin Ahn Ho-Woo Nam Tong-Soo Kim Dongjae Kim |
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Affiliation: | 1.Department of Biomedicine Health Science, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; 2.Department of Tropical Medicine, Inha University School of Medicine, Incheon 22212, Korea; 3.Department of Parasitology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; 4.Department of Medical Environmental Biology, Chung-Ang University College of Medicine, Seoul 06974, Korea; 5.Genbody Inc., Cheonan 31116, Korea |
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Abstract: | Toxoplasma gondii seroprevalence have been rapidly increasing in some parts of Korea. We analyzed prevalence of anti-Toxoplasma gondii antibodies, using a rapid diagnostic test (RDT), in the sera of 552 residents in Ganghwa-gun, 661 ones in Cheorwon-gun, and 305 ones in Goseong-gun, Korea in 2019. IgG/IgM RDT mounted with recombinant fragment of major surface antigen (SAG1), glutathione-S-transferase-linker-SAG1A, were applied to the sera. IgG seroprevalence was 28.1% in Ganghwa-gun, 19.5% in Cheorwon-gun and 35.7% in Goseong-gun. Odds ratios comparing Cheorwon vs Ganghwa was 0.63 (P=0.001) and Goesong versus Ganghwa was 1.47 (P=0.01) adjusting age and sex. Goseong had highest seroprevalence among the 3 counties both in crude rates and logistic regression. Although Cheorwon and Goseong are adjacent to the demilitarized zone (DMZ) in Korea, seroprevalence rate was much higher in Goseong. Further investigation on other DMZ-closed areas is necessary whether they have high prevalence rates compared to the other areas. T. gondii prevalence in Korea is still persists; proper health policy should be established. |
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Keywords: | Toxoplasmosis sroprevalence IgG IgM rapid diagnostic test |
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