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IL-21-IgFc immunotherapy alters transcriptional landscape of lymph node cells leading to enhanced flu vaccine response in aging and SIV infection
Authors:Suresh Pallikkuth  Daniel Kvistad  Tirupataiah Sirupangi  Alexander Kizhner  Rajendra Pahwa  Mark J. Cameron  Brian Richardson  Sion Williams  Ana Ayupe  Marissa Brooks  Constantinos Petrovas  Francois Villinger  Savita Pahwa
Affiliation:1. Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, Florida, USA;2. New Iberia Research Center and Department of Biology, University of Louisiana at Lafayette, New Iberia, Louisiana, USA;3. Department of Quantitative and Population Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA;4. Department of Neurology, Onco-Genomics Shared Resource, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida, USA;5. Onco-Genomics Shared Resource, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida, USA;6. Tissue Analysis Core, Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, USA

Department of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland

Abstract:
Keywords:aging and immune response  aging and SIV  IL-21 and Tfh cells  IL-21 and vaccine response  immunomodulation in aging
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