Exosomes from adipose‐derived stem cells and application to skin wound healing |
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| Authors: | Yang An Shuyan Lin Xiaojie Tan Shiou Zhu Fangfei Nie Yonghuan Zhen Luosha Gu Chunlei Zhang Baicheng Wang Wei Wei Dong Li Junhao Wu |
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| Affiliation: | 1. Department of Plastic Surgery, Peking University Third Hospital, Beijing China ; 2. Hearing Ctr, Department of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu China ; 3. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu China ; 4. Institute of Systems Biomedicine, Peking University, Beijing China ; 5. Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing China |
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| Abstract: | Skin wound healing is an intractable problem that represents an urgent clinical need. To solve this problem, a large number of studies have focused on the use of exosomes (EXOs) derived from adipose‐derived stem cells (ADSCs). This review describes the mechanisms whereby ADSCs‐EXOs regulate wound healing and their clinical application. In the wound, ADSCs‐EXOs modulate immune responses and inflammation. They also promote angiogenesis, accelerate proliferation and re‐epithelization of skin cells, and regulate collagen remodelling which inhibits scar hyperplasia. Compared with ADSCs therapeutics, ADSCs‐EXOs have highly stability and are easily stored. Additionally, they are not rejected by the immune system and have a homing effect and their dosage can be easily controlled. ADSCs‐EXOs can improve fat grafting and promote wound healing in patients with diabetes mellitus. They can also act as a carrier and combined scaffold for treatment, leading to scarless cutaneous repair. Overall, ADSCs‐EXOs have the potential to be used in the clinic to promote wound healing. |
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| Keywords: | adipose‐ derived stem cells, angiogenesis, exosomes, inflammation, skin wound healing |
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