Hormone interactions in the sertoli cells |
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Authors: | Anna Steinberger Jason Walther Jerrold J Heindel Barbara M Sanborn Yu-hui Tsai Emil Steinberger |
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Institution: | (1) Department of Reproductive Medicine and Biology, The University of Texas Medical School at Houston, P.O. Box 20708, 77025 Houston, Texas |
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Abstract: | Summary The effects of follicle-stimulating hormone (FSH) and testosterone in rat Sertoli cells were investigated in vitro by means
of isolated cell populations. The Sertoli cells selectively bind FSH, and respond to FSH stimulation with increased accumulation
of endogenous cyclic AMP and secretion of androgen-binding protein (ABP). FSH binding and cyclic AMP response in the Sertoli
cells change dramatically during sexual maturation. Cyclic AMP response decreases despite an increase in FSH-binding receptors
per cell. Evidence has been provided for the existence of cytoplasmic and nuclear androgen receptors and chromatin acceptor-sites
that specifically bind the androgen-receptor complex in the Sertoli cells. A model has been proposed for the hormonal interactions
in the seminiferous tubule and the possible role of Sertoli cells in mediating the hormonal effects on spermatogenesis.
Presented in the formal symposium on Sexual Differentiation in Vitro and in Vivo at the 29th Annual Meeting of the Tissue
Culture Association, Denver, Colorado, June 4–8, 1978.
This work was supported by Grant P50 HD08338 from the NICHHD. Dr. barbara M. Sanborn is a recipient of Research Career Development
Award 1-K04-HD00126 (NIH). |
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Keywords: | Sertoli cells FSH testosterone cyclic AMP hormone receptors sexual maturation |
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