Ulteriori considerazioni sul meccanismo di azione della Griseofulvina nella terapia delle dermofizie

Summary The Author gives his theory on the mechanism of action of griseofulvin in the process of recovery from dermatomycoses.The concept of an unhabitability of the str. corneum as a sequel of griseofulvin saturation seems to the A. to be unacceptable in the light of the most recent investigations. The antimycotic activity of griseofulvin is not sufficient to explain the therapeutic effect obtainable, and it can only justify the refractoriness to experimental infections in animals and in superinfection in man.In the recovery process from dermatomycoses griseofulvin intervenes as a slowing factor on the progress of the mycoses, adding its effect to the natural expulsive forces of the epidermis and hair structure, and thus, leading to a definite cure.The A. underlines the added value of the non-antimycotic, pharmacologic action of griseofulvin (anti-inflammatory, vascular, pilogenetic), demonstrated by the A. self and by other research workers in the healing process of dermatomycoses.