Proliferating CD4+ T cells undergo immediate growth arrest upon cessation of TCR signaling in vivo |
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Authors: | Yarke Cory A Dalheimer Stacy L Zhang Na Catron Drew M Jenkins Marc K Mueller Daniel L |
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Affiliation: | Department of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis 55455, USA. |
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Abstract: | To investigate the role of TCR signaling in the exit of CD4+ T cells from cell cycle, we took advantage of a low frequency TEa T cell adoptive transfer technique as well as the Y-Ae mAb to interrupt Ag/MHC recognition before the completion of clonal expansion. Termination of TCR signaling after 36 h of Ag exposure caused an immediate reduction in cell size and deceleration of G1->SG2M phase cell cycle progression. As a consequence, clonal expansion in the absence of durable TCR signaling decreased by two-thirds. Thus, CD4+ T cells scan for the presence Ag throughout their clonal expansion response, and continuously adjust their rate of cell growth and G1->S phase transition to match their intensity of TCR signaling. |
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