Mitochondria in innate immunity |
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Authors: | Arnoult Damien Soares Fraser Tattoli Ivan Girardin Stephen E |
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Affiliation: | INSERM U, Hopital Paul Brousse, Batiment Lavoisier, Villejuif, France. |
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Abstract: | Mitochondria are cellular organelles involved in host-cell metabolic processes and the control of programmed cell death. A direct link between mitochondria and innate immune signalling was first highlighted with the identification of MAVS-a crucial adaptor for RIGI-like receptor signalling-as a mitochondria-anchored protein. Recently, other innate immune molecules, such as NLRX1, TRAF6, NLRP3 and IRGM have been functionally associated with mitochondria. Furthermore, mitochondrial alarmins-such as mitochondrial DNA and formyl peptides-can be released by damaged mitochondria and trigger inflammation. Therefore, mitochondria emerge as a fundamental hub for innate immune signalling. |
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Keywords: | mitochondria innate immunity MAVS pathogen host metabolism |
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