Effects of [des-Tyr-D-Phe3]beta-casomorphin (2-5) on sleep pattern in rats. |
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Authors: | S Schulz M Diedrich W Wetzel H Matthies |
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Institution: | Institute of Pharmacology and Toxicology, Medical Academy, Magdeburg, Germany. |
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Abstract: | The effects of the antidepressant-like acting peptide des-Tyr-D-Phe3]beta-casomorphin(2-5) (Pro-D-Phe-Pro-Gly, BCH-325) on sleep were studied in rats. The rats received subcutaneous injections of BCH-325 in acute experiments (doses: 4, 20, 100, 500 and 2500 nmol/kg) and in a 10-day chronic experiment (50 nmol/kg/day). Acute administration of 20 and 100 nmol/kg enhanced wakefulness, 500 and 2500 nmol/kg enhanced paradoxical sleep, and 4 nmol/kg had no effect. Chronic administration resulted in an increase of paradoxical sleep during the first 5 days of drug treatment. Thus the sleep effects of BCH-325 differ from those of typical antidepressants and other psychotropic drugs. |
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