Enzymatic formation of 14,15-leukotriene A and C(14)-sulfur-linked peptides |
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| Authors: | D E Sok C O Han W R Shieh B N Zhou C J Sih |
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| Institution: | School of Pharmacy, University of Wisconsin, Madison, WI 53706 USA |
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| Abstract: | Human leukocytes converted 3H]-(S)-15-HPETE into 3H]-14,15-LTA. Rat basophilic leukemia cells transformed 14,15-LTA into two bioactive C(14)-S-linked peptides, which have been characterized as 15(S)-hydroxy-14(R)-S-glutathionyl-5,8,10,12-icosatetraenoic acid and 15-(S)-hydroxy-14(R)-S-cysteinylglycyl-5,8,10,12-icosatetraenoic acid by comparison with synthetic specimens. |
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| Keywords: | To whom reprint requests should be addressed |
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