| TRAIL诱导肿瘤细胞凋亡的分子机制及其在肿瘤生物治疗中的应用前景 |
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| 引用本文： | 朱玲,王祥喜,李雪梅,杨金亮.TRAIL诱导肿瘤细胞凋亡的分子机制及其在肿瘤生物治疗中的应用前景[J].生物物理学报,2012(6):448-456. |
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| 作者姓名： | 朱玲 王祥喜 李雪梅 杨金亮 |
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| 作者单位： | 四川大学华西医院生物治疗国家重点实验室;中国科学院生物物理研究所生物大分子国家重点实验室 |
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| 基金项目： | “重大新药创制”科技重大专项(2012ZX09103-301-030)~~ |
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| 摘 要： | 肿瘤坏死因子相关的凋亡诱导配体(tumor necrosis factor related apoptosis-inducingligand,TRAIL)是肿瘤坏死因子超家族成员之一,由于它能特异性诱导肿瘤细胞的凋亡而对正常细胞无毒性,因此具有被开发成治疗肿瘤的蛋白质药物的可能性。目前已经有5个与TRAIL相关的受体被鉴定出,其中,TRAILR1和TRAILR2是与诱导细胞凋亡最直接相关的受体,也是最具有前景的药物设计靶点。本文基于TRAIL蛋白及其受体复合物的三维结构分析,阐述TRAIL诱导肿瘤细胞凋亡的机制以及影响凋亡的因素和途径,对以TRAIL为靶点的肿瘤治疗的研究现状作全面综述,为探索肿瘤生物治疗的新方法和途径提供帮助。
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| 关 键 词： | TRAIL 受体 三维结构 细胞凋亡 |
Mechanism of TRAIL Induced Tumor Cell Apoptosis and Application of TRAIL Based on Tumor Therapy |
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| ZHU Ling,WANG Xiangxi,LI Xuemei,YANG Jinliang.Mechanism of TRAIL Induced Tumor Cell Apoptosis and Application of TRAIL Based on Tumor Therapy[J].Acta Biophysica Sinica,2012(6):448-456. |
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| Authors: | ZHU Ling WANG Xiangxi LI Xuemei YANG Jinliang |
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| Institution: | 1.The State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu 610041,China; 2.State Key Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China |
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| Abstract: | Apoptosis Tumor necrosis factor(TNF)-related apoptosis-inducing ligand(TRAIL) belongs to a small subset of proapoptotic protein ligands in the TNF superfamily.Tumor cells are significantly more sensitive to TRAIL-induced apoptosis than normal cells,so it’s an important potential therapeutic target for the treatment of cancer.As far as now,5 TRAIL receptors have been indentified,of which TRAILR1 and TRAILR2 are promising targets for cancer therapy.Herein we review what is known about the molecular control of TRAIL-mediated apoptosis,based on analyzing the complex structure of TRAIL with its receptor,and the potential therapeutic utility of recombinant TRAIL in antitumor study. |
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| Keywords: | TRAIL Receptor Three dimensional protein structure Apoptosis |
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