High-Level folate production in fermented foods by the B12 producer Lactobacillus reuteri JCM1112 |
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Authors: | Santos Filipe Wegkamp Arno de Vos Willem M Smid Eddy J Hugenholtz Jeroen |
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Institution: | Kluyver Centre for Genomics of Industrial Fermentation, TI Food and Nutrition, and NIZO food research, Kernhemseweg 2, P.O. Box 20, 6710 BA Ede, The Netherlands. |
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Abstract: | We observed that Lactobacillus reuteri JCM1112 produces B(12) and folate. However, the folate/B(12) mass ratio found was far below that desired for human consumption ( approximately 170:1). We used metabolic engineering applying genetic and physiological approaches to improve this ratio and developed a generic and natural process that significantly increases folate production. |
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