Oleanolic acid and ursolic acid affect peptidoglycan metabolism in <Emphasis Type="Italic">Listeria monocytogenes</Emphasis> |
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Authors: | Anna Kurek Anna M Grudniak Magdalena Szwed Anna Klicka Lukasz Samluk Krystyna I Wolska Wirginia Janiszowska Magdalena Popowska |
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Institution: | (1) Department of Bacterial Genetics, Institute of Microbiology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland;(2) Department of Plant Biochemistry, Institute of Biochemistry, University of Warsaw, Warsaw, Poland;(3) Department of Applied Microbiology, Institute of Microbiology, University of Warsaw, Warsaw, Poland |
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Abstract: | The plant pentacyclic triterpenoids, oleanolic and ursolic acids, inhibit the growth and survival of many bacteria, particularly
Gram-positive species, including pathogenic ones. The effect of these compounds on the facultative human pathogen Listeria monocytogenes was examined. Both acids affected cell morphology and enhanced autolysis of the bacterial cells. Autolysis of isolated cell
walls was inhibited by oleanolic acid, but the inhibitory activity of ursolic acid was less pronounced. Both compounds inhibited
peptidoglycan turnover and quantitatively affected the profile of muropeptides obtained after digestion of peptidoglycan with
mutanolysin. These results suggest that peptidoglycan metabolism is a cellular target of oleanolic and ursolic acids. |
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