Decreased frequency and activated phenotype of blood CD27 IgD IgM B lymphocytes is a permanent abnormality in systemic lupus erythematosus patients期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Decreased frequency and activated phenotype of blood CD27 IgD IgM B lymphocytes is a permanent abnormality in systemic lupus erythematosus patients

Authors:	Beatriz Rodríguez-Bayona Ana Ramos-Amaya José J Pérez-Venegas Carmen Rodríguez José A Brieva

Institution:	1.Unidad de Investigación, Hospital Universitario Puerta del Mar,Cádiz,Spain;2.Sección de Reumatología, Hospital de Jerez,Jerez de la Frontera,Spain;3.Servicio de Inmunología,Hospital Universitario Puerta del Mar,Cádiz,Spain

Abstract:	Introduction Systemic lupus erythematosus (SLE) is characterized by B cell hyper-activation and auto-reactivity resulting in pathogenic auto-antibody generation. The phenotypic analysis of blood B cell subsets can be used to understand these alterations.

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