Protective Effects of Hypothalamic Proline-Rich Peptide and Cobra Venom Naja Naja Oxiana on Dynamics of Vestibular Compensation Following Unilateral Labyrinthectomy |
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Authors: | Armen A Galoyan Naser Khalaji Lilja E Hambardzumyan Larisa P Manukyan Irina B Meliksetyan Vergine A Chavushyan Vaghinak H Sarkisian John S Sarkissian |
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Institution: | (1) Buniatian Institute of Biochemistry, NAS RA, Yerevan, Republic of Armenia;(2) Orbeli Institute of Physiology, NAS RA, Yerevan, Republic of Armenia; |
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Abstract: | We tested the action of proline-rich peptide (PRP-1) and cobra venom Naja Naja Oxiana (NOX) on Deiters’ nucleus neurons at
3rd, 15th and 35th days after unilateral labyrinthectomy (UL). Early and late tetanic, post-tetanic potentiation and depression
of Deiters’neurons to bilateral high frequency stimulation of hypothalamic supraoptic and paraventricualar nuclei was studied.
The analysis of spike activity was carried out by mean of on-line selection and special program. The complex averaged peri-event
time and frequency histograms shows the increase of inhibitory and excitatory reactions of Deiters’ neurons at early stage
of vestibular compensation following PRP-1 and NOX injection, reaching the norm at the end of tests. In histochemical study
the changes in Ca2+-dependent acidic phosphatase (AP) activity in neurons was discovered. It was shown that in UL animals the total disappearance
or delay of decolorizing of Deiters’ neurons lead to neurodegenerative pattern as cellular “shade”. AP activity after UL and
PRP-1 injection exerts more effective recovery of neurons in comparison with events, observed after the administration of
NOX. The data of this study indicate that PRP-1 and NOX are protectors, which may successfully recover the disturbed vestibular
functions. |
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