| 核酸适配体及其在病原微生物学中的应用 |
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| 引用本文： | 梁红茹,杨松涛,张涛,胡桂秋,夏咸柱. 核酸适配体及其在病原微生物学中的应用[J]. 生物工程学报, 2011, 27(5): 698-703 |
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| 作者姓名： | 梁红茹 杨松涛 张涛 胡桂秋 夏咸柱 |
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| 作者单位： | 1. 吉林大学畜牧兽医学院,长春,130062;军事医学科学院军事兽医研究所,长春,130062
2. 军事医学科学院军事兽医研究所,长春,130062 |
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| 摘 要： | 核酸适配体指利用指数富集配体系统进化技术筛选出的寡聚核苷酸片段，它可以特异性地识别靶标并与之结合，已经广泛应用于基础研究、临床诊断、纳米技术等。以下综述了适配体在微生物学方面的应用。
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| 关 键 词： | 适配体，病毒，细菌，指数富集配体系统进化技术 |
| 收稿时间： | 2010-12-22 |
Aptamers: characteristics and applications in pathogenic microorganism |
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| Hongru Liang,Songtao Yang,Tao Zhang,Guiqiu Hu and Xianzhu Xia. Aptamers: characteristics and applications in pathogenic microorganism[J]. Chinese journal of biotechnology, 2011, 27(5): 698-703 |
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| Authors: | Hongru Liang Songtao Yang Tao Zhang Guiqiu Hu Xianzhu Xia |
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| Affiliation: | College of Animal Science and Veterinary, Jilin University, Changchun 130062, China; Institute of Military Veterinary, Academy of Military Medical Science, Changchun 130062, China;Institute of Military Veterinary, Academy of Military Medical Science, Changchun 130062, China;Institute of Military Veterinary, Academy of Military Medical Science, Changchun 130062, China;Institute of Military Veterinary, Academy of Military Medical Science, Changchun 130062, China;Institute of Military Veterinary, Academy of Military Medical Science, Changchun 130062, China |
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| Abstract: | Aptamers are a group of artificial oligonucleotides identified by exponential enrichment system evolution technology (Selective expansion of ligands by exponential enrichment, SELEX). Aptamers have been widely used in basic research, clinical diagnostics, and nano-technology. In this article we will introduce the technology of aptamer and summarize its applications in medical microbiology. |
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| Keywords: | aptamer virus bacteria selective expansion of ligands by exponential enrichment (SELEX) |
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