| 高原低氧对大鼠大脑皮质生长休止蛋白7表达的影响 |
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| 引用本文： | 李晓恒,孙朝越,胡红梅,杨赣军,孙弋,彭建安,廖家万. 高原低氧对大鼠大脑皮质生长休止蛋白7表达的影响[J]. 中国组织化学与细胞化学杂志, 2011, 20(4): 331-333. DOI: 10.3870/zgzzhx.2011.04.008 |
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| 作者姓名： | 李晓恒 孙朝越 胡红梅 杨赣军 孙弋 彭建安 廖家万 |
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| 作者单位： | 1. 井冈山大学医学院组织胚胎学教研室,江西,343300;深圳市疾病预防控制中心,广东,518055
2. 井冈山大学医学院组织胚胎学教研室,江西,343300 |
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| 基金项目： | 江西省自然科学基金资助 |
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| 摘 要： | 目的 探讨高原低氧对大鼠大脑皮质生长休止蛋白7(Gas7)表达的影响.方法 36只大鼠随机分为正常对照组和模拟高原低氧组,模拟高原低氧组大鼠进行6周缺氧,复制慢性高原低氧动物模型.实验结束后,所有动物采用免疫组织化学和免疫印迹技术检测大鼠大脑皮质中Gas7的表达.结果 与对照组相比,Gas7在模拟高原低氧组大鼠大脑皮质的表达明显增强.结论 Gas7可能参与了高原低氧对大鼠大脑皮质神经元结构和功能的影响.
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| 关 键 词： | 神经元 高原低氧 |
Effects of high altitude hypoxia on the expression of Growth-arrest-specific protein 7 in rat cerebral cortex |
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| Li Xiaoheng,Sun Chaoyue,Hu Hongmei,Yang Ganjun,Sun Yi,Peng Jianan,Liao Jiawan. Effects of high altitude hypoxia on the expression of Growth-arrest-specific protein 7 in rat cerebral cortex[J]. Chinese Journal of Histochemistry and Cytochemistry, 2011, 20(4): 331-333. DOI: 10.3870/zgzzhx.2011.04.008 |
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| Authors: | Li Xiaoheng Sun Chaoyue Hu Hongmei Yang Ganjun Sun Yi Peng Jianan Liao Jiawan |
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| Affiliation: | Li Xiaoheng2,Sun Chaoyue1,Hu Hongmei1,Yang Ganjun1,Sun Yi1,Peng Jianan1,Liao Jiawan1*(1Department of Histology and Embryology,Medical college of Jing Gang Shan University,Jiangxi 343300,2Shenzhen Center for Disease Control and Prevention,Guangdong 518055,China) |
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| Abstract: | Objective To study the effect of high altitude hypoxia on the expression of growtharrest-specific protein 7(Gas7) in the cerebral cortex of rats.Methods Thirty-six adult male Wistar rats were randomly divided into the control group and the simulated high altitude hypoxia group.Rats in the latter group were exposed to simulated high altitude hypoxia for 6 weeks achiere the hypoxia models.Then the expression of Gas7 protein in the cerebral cortex of rats was assayed by using immunocytochemistry and western-bl... |
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| Keywords: | Gas7 |
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