Synthesis and cytotoxicity of 3,4-diaryl-2(5H)-furanones |
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Authors: | Kim Yong Nam Nguyen-Hai You Young-Jae Ahn Byung-Zun |
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Institution: | College of Pharmacy, Chungnam National University, Taejon 305-764, Republic of Korea. |
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Abstract: | A series of 3,4-diaryl-2(5H)-furanone derivatives were synthesized and evaluated for their cytotoxicity in a small panel of cancer cell lines. Four out of 10 compounds in this series, for example 3-(3,4,5-trimethoxyphenyl)-4-(4-methoxyphenyl)-, 3-(3,4,5-trimethoxyphenyl)-4-(3-hydroxy-4-methoxyphenyl)-, 3-(3,4,5-trimethoxyphenyl)-4-(3-amino-4-methoxyphenyl)-, and 3-(3,4,5-trimethoxyphenyl)-4-(2-naphthyl)-2(5H)-furanones, were found to have potent cytotoxic activities with ED50 values of less than 20 nM in most of the cell lines tested. |
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