Serotonergic control of the heart and pericardium in the chiton Acanthopleura japonica |
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| Authors: | Shinji Matsumura Makoto Kurokawa Kiyoaki Kuwasawa Robert B. Hill Kenji Ohsuga |
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| Affiliation: | a Department of Biological Sciences, Tokyo Metropolitan University, Minami-Ohsawa 1-1, Hachioji-shi, Tokyo 192-0397, Japan;b Department of Biological Sciences, University of Rhode Island, Kingston, RI 02881, USA |
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| Abstract: | Serotonergic control of the heart and pericardium of the chiton, Acanthopleura japonica, was examined during this combined histological and physiological study. Glyoxylic acid (2%) induced fluorescence in neural elements of fibers and varicosities in the heart and pericardium. Serotonin exerted positive chronotropic and inotropic actions on the heart and pericardium in a dose-dependent manner. The threshold dose of serotonin that stimulated excitatory effects on the heart and pericardium was less than 10−9 M. The histological and pharmacological results suggest that serotonin may be a neurotransmitter present in excitatory nerves innervating the heart and pericardium. We conclude that serotonergic excitatory control of the heart appeared early during molluscan phylogeny with the evolution of the chitons. The pericardium of the chiton may receive serotonergic excitatory neural control, which has not been reported in higher molluscan taxa. |
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| Keywords: | Chiton Heart Pericardium Serotonin Chronotropic effect Inotropic effect Excitatory innervation Methysergide Neural control Glyoxylic acid |
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