mRNA at synapses,synaptic plasticity,and memory consolidation |
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| Authors: | Steward Oswald |
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| Institution: | Reeve-Irvine Research Center, Department of Anatomy and Neurobiology, Department of Neurobiology and Behavior, University of California at Irvine, Irvine, CA 92697, USA. |
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| Abstract: | Miller et al. (this issue of Neuron) report that deletion of the 3'UTR of alpha-CaMKII mRNA prevents dendritic delivery of the mRNA in transgenic mice and thus local synthesis of alpha-CaMKII protein in dendrites. 3'UTR mutant mice exhibit decreases in alpha-CaMKII protein in postsynaptic densities, and deficits in late phase LTP and in memory consolidation. |
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