| The nucleolus： reviewing oldies to have new understandings |
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| 引用本文： | Lo SJ,Lee CC,Lai HJ. The nucleolus： reviewing oldies to have new understandings[J]. Cell research, 2006, 16(6): 530-538 |
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| 作者姓名： | Lo SJ Lee CC Lai HJ |
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| 作者单位： | [1]Department of Life Science, Graduate Institute of Basic Medical Science, 259, Wen-Hwa 1st Road, Chang Gung University, Tao Yuan [2]Institute of Microbiology and Immunology, National Yang Ming University, Taipei 112 |
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| 基金项目： | We thank Dr NH Yeh （National Yang-Ming University） for her long-term discussion and providing us data prior publication. The work of C. elegans was supported by grants （CMRPD32037 and CMRPDI40041） from the Chang Gung Memorial Hospital. |
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| 摘 要： | The nucleolus is the most prominent compartment in the nucleus and known as the site for ribosome biogenesis ineucaryotes.In contrast,there is no such equivalent structure for ribosome synthesis in procaryotes.This raises twoconcerns that how does the nucleolus evolve and that whether the nucleolus remains playing a single role in ribosomebiogenesis along the evolution.Increasing data support new nucleolus functions,including signal recognition particleassembly,small RNA modification,telomerase maturation,cell-cycle and aging control,and cell stress sensor.Multiplefunctions of the nucleolus possibly result from the plurifunctionality of nucleolar proteins,such as nucleolin and Nopp 140.Proteomic analyses of human and Arabidopsis nucleolus lead a remarkable progress in understanding the evolution andnew functions of nucleoli.In this review,we present a brief history of nucleolus research and new concepts and unre-solved questions.Also,we introduce hepatitis D virus for studying the communication between the nucleolus and othersubnuclear compartments,and Caenorhabditis elegans for the role of nucleolus in the development and the epistaticcontrol of nucleologenesis.
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| 关 键 词： | 核仁 老年 核糖体 生源学 |
The nucleolus: reviewing oldies to have new understandings |
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| Lo Szecheng J,Lee Chi-Chang,Lai Huey-Jen. The nucleolus: reviewing oldies to have new understandings[J]. Cell research, 2006, 16(6): 530-538 |
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| Authors: | Lo Szecheng J Lee Chi-Chang Lai Huey-Jen |
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| Affiliation: | Department of Life Science, Graduate Institute of Basic Medical Science, 259, Wen-Hwa 1st Road, Chang Gung University, TaoYuan 333. losj@mail.cgu.edu.tw |
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| Abstract: | The nucleolus is the most prominent compartment in the nucleus and known as the site for ribosome biogenesis in eucaryotes. In contrast, there is no such equivalent structure for ribosome synthesis in procaryotes. This raises two concerns that how does the nucleolus evolve and that whether the nucleolus remains playing a single role in ribosome biogenesis along the evolution. Increasing data support new nucleolus functions, including signal recognition particle assembly, small RNA modification, telomerase maturation, cell-cycle and aging control, and cell stress sensor. Multiple functions of the nucleolus possibly result from the plurifunctionality of nucleolar proteins, such as nucleolin and Nopp 140. Proteomic analyses of human and Arabidopsis nucleolus lead a remarkable progress in understanding the evolution and new functions of nucleoli. In this review, we present a brief history of nucleolus research and new concepts and unresolved questions. Also, we introduce hepatitis D virus for studying the communication between the nucleolus and other subnuclear compartments, and Caenorhabditis elegans for the role of nucleolus in the development and the epistatic control of nucleologenesis. |
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| Keywords: | evolution of the nucleolus HDV Nopp 140 nucleolin nucleolome |
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