| 基于动脉管壁的脂联素球状域保护机理 |
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| 引用本文： | 王平平,尹卫东.基于动脉管壁的脂联素球状域保护机理[J].生命的化学,2012(2):127-130. |
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| 作者姓名： | 王平平 尹卫东 |
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| 作者单位： | 南华大学心血管病研究所,衡阳421001 |
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| 摘 要： | 脂肪细胞分泌产物脂联素(adiponectin,APN)的发现是脂肪内分泌学研究领域的重大进展。它主要通过与相应受体结合,发挥相应的生物学效应,且其心血管保护作用目前已成为研究热点。动脉管壁上也存在其受体,在此基础上,将APN活性区域的脂联素球状域(globular domain of adiponectin,gAd)设计为新靶点,研究其对动脉管壁的保护作用及其相关机理,将为动脉粥样硬化疾病的防治提供新方案。
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| 关 键 词： | 脂联素球状域 脂联素受体 保护机理 动脉管壁 |
Protective mechanism of globular adiponectin based on arteral wall |
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| WANG Pingping,YIN Weidong.Protective mechanism of globular adiponectin based on arteral wall[J].Chemistry of Life,2012(2):127-130. |
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| Authors: | WANG Pingping YIN Weidong |
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| Institution: | Institute of Cardiovascular Disease,University of South China,Hengyang 421001,China |
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| Abstract: | Adiponectin is a protein secreted exclusively by white adipose tissue and is abundantly present in human plasma.It has essential biological effects,and its protective effects on arteral wall have become a research hotspot.The globular domain of adiponectin is considered to be bioactive.It is a new target for studying the protective mechanism for vascular wall,which may have great significance in the preventive and therapeutic strategies of atherosclerosis. |
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| Keywords: | globular adiponectin adiponectin receptors protective mechanism vascular wall |
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