| PUMA对人体肿瘤的促凋亡作用 |
| |
| 引用本文： | 刘春菊,万福生.PUMA对人体肿瘤的促凋亡作用[J].生命的化学,2012(1):23-28. |
| |
| 作者姓名： | 刘春菊 万福生 |
| |
| 作者单位： | 南昌大学基础医学院生物化学与分子生物学教研室,南昌330006 |
| |
| 基金项目： | 江西省自然科学基金项目（2010JZY0237）资助 |
| |
| 摘 要： | p53上调凋亡调控因子(p53 up-regulated modulator of apoptosis,PUMA)是Bcl-2蛋白家族的促凋亡成员之一,具有强大的促凋亡作用。研究发现PUMA表达水平降低与肿瘤的发生密切相关,上调肿瘤细胞中PUMA的表达可以增强肿瘤细胞对放化疗的敏感性,说明PUMA是一个非常有前景的肿瘤基因治疗靶点。本文简要综述了PUMA对人体肿瘤促凋亡作用的研究进展。
|
| 关 键 词： | PUMA 肿瘤 促凋亡 基因治疗 |
Pro-apoptotic function of PUMA in human tumor |
| |
| LIU Chunju,WAN Fusheng.Pro-apoptotic function of PUMA in human tumor[J].Chemistry of Life,2012(1):23-28. |
| |
| Authors: | LIU Chunju WAN Fusheng |
| |
| Institution: | Department of Biochemistry and Molecular Biology,Basic Medical College of Nanchang University,Nanchang 330006,China |
| |
| Abstract: | p53 up-regulated modulator of apoptosis（PUMA） is a member of the Bcl-2 family and has powerful proapoptotic functions.The studies showed that the decrease expression of PUMA was closely related to the occurrence of tumor and upregulation expression of PUMA could enhance tumor sensitivity to radiotherapy and chemotherapy.So PUMA is potentially useful in gene therapy.Here we review the pro-apoptotic research progress of PUMA in human tumor. |
| |
| Keywords: | PUMA tumor pro-apoptotic gene therapy |
| 本文献已被 CNKI 维普 等数据库收录！ |
