| miRNA调控骨髓增生异常综合征的发生发展 |
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| 引用本文： | 廖荣霞,谌谐婉,詹小青,陈敏.miRNA调控骨髓增生异常综合征的发生发展[J].生命的化学,2012(1):52-54. |
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| 作者姓名： | 廖荣霞 谌谐婉 詹小青 陈敏 |
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| 作者单位： | 第三军医大学基础部医学英语教研室,重庆400038 |
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| 基金项目： | 国家自然科学基金面上项目（30971289）; 第三军医大学科研基金（2007D172）资助 |
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| 摘 要： | 骨髓增生异常综合征(MDS)是一组起源于造血干细胞(HSC)的异质性克隆性疾患,以形态学改变(病态造血)和造血功能异常(无效造血)为主要特征,然而其发生、发展及白血病转化的分子机制尚不明确。MicroRNA(miRNA)是一类重要的非编码小分子RNA,在调控造血干细胞发育进程中起着重要作用,其在MDS的发生发展及白血病转化中的作用也逐渐被认识,以miRNA为分子靶点诊治造血干细胞受损疾患的研究具有广阔的应用前景。
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| 关 键 词： | 造血干细胞 microRNA 骨髓增生异常综合征 干细胞疾病 |
MicroRNAs regulate the genesis and the development of myelodysplastic syndrome |
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| LIAO Rongxia,CHEN Xiewan,ZHAN Xiaoqing,CHEN Min.MicroRNAs regulate the genesis and the development of myelodysplastic syndrome[J].Chemistry of Life,2012(1):52-54. |
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| Authors: | LIAO Rongxia CHEN Xiewan ZHAN Xiaoqing CHEN Min |
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| Institution: | Medical English Department,Third Military Medical University,Chongqing 400038,China |
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| Abstract: | Myelodysplastic syndrome（MDS） has been known as a heterogeneous clonal disorder of hematopoietic stem cells（HSCs）,which is primarily characterized by morphological changes（myelodysplasia） and abnormal hematopoiesis（ineffective hematopoiesis）.However,the molecular mechanism of MDS genesis and development and leukemic transformation remains unclear.MicroRNAs（miRNAs） are small non-coding RNAs functioning as regulators of HSC development.With their roles being elucidated,miRNAs have become potential targets for diagnosing stem cell diseases. |
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| Keywords: | hematopoietic stem cells microRNA myelodysplastic syndrome stem cell disease |
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