| PAD4参与中性粒细胞胞外诱捕网的抗菌作用 |
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| 引用本文： | 周剑涛,丁海峰,姚振国.PAD4参与中性粒细胞胞外诱捕网的抗菌作用[J].生命的化学,2012(1):44-46. |
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| 作者姓名： | 周剑涛 丁海峰 姚振国 |
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| 作者单位： | [1]黄冈职业技术学院医药卫生学院,黄冈438000 [2]黄冈市中心医院,黄冈438000 |
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| 摘 要： | 蛋白质精氨酸脱亚氨酶4(PAD4)是中性粒细胞胞外诱捕网(NET)介导的细菌杀灭途径中的重要免疫因子。PAD4催化组蛋白瓜氨酸化,促进细菌感染期中性粒细胞形成NET。PAD4/中性粒细胞在炎性因子或细菌作用下不能形成NET,PAD4/鼠相对于PAD4+/+鼠更易受细菌感染。
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| 关 键 词： | 蛋白质精氨酸脱亚氨酶4 细胞外诱捕网 抗菌作用 中性粒细胞 |
PAD4 is essential for NET-mediated antibacterial function |
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| ZHOU Jiantao,DING Haifeng,YAO Zhenguo.PAD4 is essential for NET-mediated antibacterial function[J].Chemistry of Life,2012(1):44-46. |
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| Authors: | ZHOU Jiantao DING Haifeng YAO Zhenguo |
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| Institution: | 1Medical and Health College of Huanggang Polytechnic University,Huanggang 438000,China 2Central Hospital of Huanggang,Huanggang 438000,China |
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| Abstract: | Peptidylarginine deiminase 4（PAD4） is an important immune factor required for neutrophil extracellular traps（NETs）-mediated anti-bacterial innate immunity.The deimination of histones by PAD4 mediates the formation of NET-like structures in neutrophils in response to bacterial infections.PAD4 / neutrophils can not form NETs after treatment with proinflammatory stimuli or incubation with bacteria.PAD4 / mice are more susceptible to bacterial infection than PAD4＋/＋mice due to the lack of NET formation. |
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| Keywords: | peptidylarginine deiminase 4 neutrophil extracellular traps antibacterial functions neutrophils |
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