| 丙烯酰胺神经系统毒性机制 |
| |
| 引用本文： | 王从荣,吴国忠,钟梅芳.丙烯酰胺神经系统毒性机制[J].生命的化学,2012(1):84-87. |
| |
| 作者姓名： | 王从荣 吴国忠 钟梅芳 |
| |
| 作者单位： | 上海医药高等专科学校基础部,上海201318 |
| |
| 基金项目： | 上海高校青年教师培养资助计划项目（shyy003）资助 |
| |
| 摘 要： | 丙烯酰胺(acrylamide,ACR)是公认的神经、致癌、遗传和雄性生殖毒物。高温(120 oC)烹饪富含淀粉食物会产生ACR及致癌性已在近年引起世界卫生组织(WHO)和联合国粮农组织(FAO)的关注,本文就ACR的性质、危害、代谢、对神经行为的影响和神经毒性机制的研究状况方面进行综述,以期为ACR对神经系统毒性作用的特点、机制及危险度评定和防治提供科学依据。
|
| 关 键 词： | 丙烯酰胺 神经毒性 氧化应激 凋亡 |
Mechanism of the neurotoxicity of acrylamide |
| |
| WANG Congrong,WU Guozhong,ZHONG Meifang.Mechanism of the neurotoxicity of acrylamide[J].Chemistry of Life,2012(1):84-87. |
| |
| Authors: | WANG Congrong WU Guozhong ZHONG Meifang |
| |
| Institution: | Department of Medical Sciences,Shanghai Institute of Health Sciences,Shanghai 201318,China |
| |
| Abstract: | Acrylamide（ACR） is recognized to have neurotoxicity,carcinogenic,genetoxic,and male reproductive toxicology.In recent years,it has been found that cooking foods rich in starch at high-temperature cooking（ 120 oC） generates ACR and carcinogenicity,which has drawn the attention of WHO/FAO.In this review,we will discuss the nature,the hazard,the metabolism,the effects of ACR to the neuroethology,and the mechanisms of neurotoxicity.We hope to provide a scientific basis for the characteristics and mechanisms of neurotoxicity of ACR,the risk assessment of ACR,the prevention and treatment of ACR. |
| |
| Keywords: | acrylamide neurotoxicity oxidative stress apoptosis |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
