Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau. |
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Authors: | E M Mandelkow G Drewes J Biernat N Gustke J Van Lint J R Vandenheede E Mandelkow |
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Institution: | Max-Planck-Unit for Structural Molecular Biology, DESY, Hamburg, Germany. |
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Abstract: | The Alzheimer-like state of tau protein includes phosphorylation by a proline-directed Ser/Thr kinase present in normal or pathological human brain. Extending earlier results on MAP kinase, we show here that the proline-directed kinase, GSK3, can induce an Alzheimer-like immune response involving several distinct and phosphorylatable epitopes at Ser-Pro motifs, as well as a gel mobility shift, similar to MAP kinase. Both kinases behave like microtubule-associated proteins in that they co-purify through cycles of assembly and disassembly, and both kinases are directly associated with paired helical filaments. |
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