Interaction of neoglycolipids with artificial membranes and erythrocytes. Influence of the length of the neoglycolipid ethoxy moiety |
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| Authors: | Micaèle Gelhausen Françoise Besson Stéphanie Bonnin Dominique Lafont Bernard Roux |
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| Affiliation: | (1) Laboratoire de Physico-Chimie Biologique, UPRESA CNRS, 5013 Lyon, France;(2) Laboratoire de Chimie Organique 2, UMR CNRS, Lyon, France;(3) Laboratoire de Physico-Chimie Biologique, UPRESA CNRS, 5013 Lyon, France |
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| Abstract: | Lengthening the spacer of N-acetyl glucosaminyl oligoethoxy cholesterol neoglycolipids from one to seven ethoxy units modified neither the neoglycolipid incorporation into liposomes nor the liposome sizes. Moreover, lengthening the spacer from three to seven units increased the 5(6)-carboxyfluorescein leakage from mixed liposomes. These neoglycolipid-induced disturbances in membrane permeability were corroborated by determining their haemolytic activities. © Rapid Science Ltd. 1998 |
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