Anticancer activity of oxovanadium compounds |
| |
| Authors: | O Yu Abakumova O V Podobed N F Belayeva A I Tochilkin |
| |
| Institution: | (1) Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, 607-8414 Kyoto, Japan;(2) Department of Chemistry, Graduate School of Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, 558-8585 Osaka, Japan;(3) Department of Materials Science and Engineering, Teikyo University, 1-1 Toyosatodai, 320-8551 Utsunomiya, Japan;; |
| |
| Abstract: | Cytotoxic and antitumor activities of the biligand vanadyl derivative of L-malic acid, (bis-(L-malato)oxovanadium(IV) (VO(mal)2), the inorganic vanadium(IV) compound, vanadyl sulfate (VOSO4), the oxovanadium monocomplex with L-malic acid (VO(mal)), and the vanadyl biscomplex with acetylacetonate (VO(acac)2) were investigated using several tumor cell lines: mouse fibrosarcoma (L929), rat pheochromocytoma (PC12), human liver carcinoma (HepG2), mouse embryonic fibroblasts (NIH/3T3), and also normal human skin fibroblasts. The results showed that VO(mal)2 effectively inhibited growth of cancer cell cultures without any toxic effect on normal human skin fibroblasts. The cytotoxic anticancer effect of vanadium complexes depended on concentration of the compounds studied, incubation time, types of cell cultures, and nature of ligands surrounding the central group of the complex (VO2+). These studies provide evidence that VO(mal)2 may be considered as a potential anticancer agent due to its low toxicity for non-tumor cells and significant anticancer activity. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
