The de novo engineering of pyrrolysyl-tRNA synthetase for genetic incorporation of L-phenylalanine and its derivatives |
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| Authors: | Wang Yane-Shih Russell William K Wang Zhiyong Wan Wei Dodd Lindsey E Pai Pei-Jing Russell David H Liu Wenshe R |
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| Institution: | Department of Chemistry, Texas A&M University, College Station, TX 77843, USA. |
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| Abstract: | Using evolved pyrrolysyl-tRNA synthetase-tRNA(CUA)(Pyl) pairs, L-phenylalanine, p-iodo-L-phenylalanine and p-bromo-L-phenylalanine have been genetically incorporated into proteins at amber mutation sites in E. coli. |
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