Intratumoral expression of IL-17 and its prognostic role in gastric adenocarcinoma patients |
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Authors: | Chen Ju-gao Xia Jian-chuan Liang Xiao-ting Pan Ke Wang Wei Lv Lin Zhao Jing-jing Wang Qi-jing Li Yong-qiang Chen Shi-ping He Jia Huang Li-xi Ke Miao-la Chen Yi-bing Ma Hai-qing Zeng Zhen-wu Zhou Zhi-wei Chang Alfred E Li Qiao |
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Affiliation: | The State Key Laboratory of Oncology in Southern China and Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou 510060, PR China. |
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Abstract: | In this study, we characterized the intratumoral expression of IL-17 and CD8(+) TILs in gastric adenocarcinoma patients after resection and determined the correlation between the survival probability of gastric adenocarcinoma patients and the expression of IL-17 in tumor. Expression of IL-17 and CD8 was assessed by immunohistochemistry, and the prognostic effects of intratumoral IL-17 expression and CD8(+) TILs were evaluated by Cox regression and Kaplan-Meier analysis. Immunohistochemical detection revealed the presence of IL-17 and CD8(+) cells in gastric adenocarcinoma tissue samples (90.6%, 174 out of 192 patients and 96.9%, 186 out of 192 patients, respectively). We have also found that intratumoral IL-17 expression was significantly correlated with age (p=0.004) and that the number of CD8(+)TILs was significantly correlated with UICC staging (p=0.012) and the depth of tumor invasion (p=0.022). The five-year overall survival probability among patients intratumorally expressing higher levels of IL-17 was significantly better than those expressing lower levels of IL-17 (p=0.036). Multivariate Cox proportional hazard analyses revealed that intratumoral IL-17 expression (HR: 0.521; 95% CI: 0.329-0.823; p=0.005) was an independent factor affecting the five-year overall survival probability. We conclude that low levels of intratumoral IL-17 expression may indicate poor prognosis in gastric adenocarcinoma patients. |
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Keywords: | IL-17 intratumoral expression gastric carcinoma prognostic indicator |
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