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Intratumoral expression of IL-17 and its prognostic role in gastric adenocarcinoma patients
Authors:Chen Ju-gao  Xia Jian-chuan  Liang Xiao-ting  Pan Ke  Wang Wei  Lv Lin  Zhao Jing-jing  Wang Qi-jing  Li Yong-qiang  Chen Shi-ping  He Jia  Huang Li-xi  Ke Miao-la  Chen Yi-bing  Ma Hai-qing  Zeng Zhen-wu  Zhou Zhi-wei  Chang Alfred E  Li Qiao
Institution:The State Key Laboratory of Oncology in Southern China and Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou 510060, PR China.
Abstract:In this study, we characterized the intratumoral expression of IL-17 and CD8(+) TILs in gastric adenocarcinoma patients after resection and determined the correlation between the survival probability of gastric adenocarcinoma patients and the expression of IL-17 in tumor. Expression of IL-17 and CD8 was assessed by immunohistochemistry, and the prognostic effects of intratumoral IL-17 expression and CD8(+) TILs were evaluated by Cox regression and Kaplan-Meier analysis. Immunohistochemical detection revealed the presence of IL-17 and CD8(+) cells in gastric adenocarcinoma tissue samples (90.6%, 174 out of 192 patients and 96.9%, 186 out of 192 patients, respectively). We have also found that intratumoral IL-17 expression was significantly correlated with age (p=0.004) and that the number of CD8(+)TILs was significantly correlated with UICC staging (p=0.012) and the depth of tumor invasion (p=0.022). The five-year overall survival probability among patients intratumorally expressing higher levels of IL-17 was significantly better than those expressing lower levels of IL-17 (p=0.036). Multivariate Cox proportional hazard analyses revealed that intratumoral IL-17 expression (HR: 0.521; 95% CI: 0.329-0.823; p=0.005) was an independent factor affecting the five-year overall survival probability. We conclude that low levels of intratumoral IL-17 expression may indicate poor prognosis in gastric adenocarcinoma patients.
Keywords:IL-17  intratumoral expression  gastric carcinoma  prognostic indicator
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