Nonsense-mediated mRNA decay: terminating erroneous gene expression |
| |
Authors: | Baker Kristian E Parker Roy |
| |
Affiliation: | Howard Hughes Medical Institute, University of Arizona, 1007 East Lowell Street, Tucson, Arizona 85721, USA. |
| |
Abstract: | Nonsense-mediated mRNA decay is a surveillance pathway that reduces errors in gene expression by eliminating aberrant mRNAs that encode incomplete polypeptides. Recent experiments suggest a working model whereby premature and normal translation termination events are distinct as a consequence of the spatial relationship between the termination codon and mRNA binding proteins, a relationship partially established by nuclear pre-mRNA processing. Aberrant termination then leads to both translational repression and an increased susceptibility of the mRNA to multiple ribonucleases. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|