The influence of some prostaglandins on DNA synthesis and DNA excision repair in mouse spleen cells |
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Authors: | D. Egg H. Altman R. Günther W. Klein F. Kocsis |
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Affiliation: | 1. Department of Internal Medicine, Univ. Inssbruck, Australia;2. Department of Biology, Research Institute Seibersdorf, Australia |
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Abstract: | experiments were performed on mouse spleen cells to establish possible influences of some naturally occurring prostaglandins on DNA synthesis and DNA excision repair. The prostaglandins A1, B1, E1, E2 and F2 were tested in concentrations of lopg, 5ng and 2.5μg per ml cell suspension. DNA synthesis was significantly increased by pgF2α in all the three concentrations tested, while the other tested prostaglandins were essentially ineffective. DNA excision repair was significantly inhibited by PgF1 and PgF2 at 5ng/'ml and at 2.5μg/ml but increased by PgF2α in the two lower concentrations. The rejoining of DNA-strand breaks after γ-irradiation was slightly reduced by PgF1, PgE2 and PgF2α at 2.5μg/ml. |
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