Role of prostaglandin F2α in modulation of LH-stimulated steroidogenesis in different types of rat and ewe corpora lutea |
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Authors: | M Evrard P Leboulleux C Hermier |
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Institution: | Laboratoire des Hormones Polypeptidiques - CNRA - 91190 Gif-sur-Yvette, France |
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Abstract: | An inhibitory effect of PGF2α at a dose of 7 × 10?7 M on LH stimulated synthesis of progesterone was observed after incubation of pseudopregnant rat ovaries for a period of 2 hours. A similar effect was seen with cyclic and gestant ewe corpora lutea at the same dose of PGF2α. This effect was observed both in the secretion of progesterone and on the amount of progesterone present in the tissue. This inhibitory effect of PGF2α on LH stimulated progesterone synthesis may explain the modification in the time course for gonadotropin action in luteal tissue at high and low doses. |
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