| Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds,2014–2015 |
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| 作者姓名： | Yuhai Bi Jianjun Chen Zhenjie Zhang Mingxin Li Tianlong Cai Kirill Sharshov Ivan Susloparov Alexander Shestopalov Gary Wong Yubang He Zhi Xing Jianqing Sun Di Liu Yingxia Liu Lei Liu Wenjun Liu Fumin Lei Weifeng Shi George F.Gao |
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| 作者单位： | Shenzhen Key Laboratory of Pathogen and Immunity,State Key Discipline of Infectious Disease,Shenzhen Third People’s Hospital;CAS Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI),Institute of Microbiology,Chinese Academy of Sciences;Center for Influenza Research and Early-warning (CASCIRE),Chinese Academy of Sciences;CAS Key Laboratory of Special Pathogens and Biosafety,Wuhan Institute of Virology Chinese Academy of Sciences;Research Institute of Experimental and Clinical Medicine,Novosibirsk State University;Institute of Pathogen Biology,Taishan Medical College;CAS Key Laboratory of Zoological Systematics and Evolution,Institute of Zoology,Chinese Academy of Sciences;Qinghai Lake National Nature Reserve,State Forestry Administration;Office of Director-General,Chinese Center for Disease Control and Prevention (China CDC),and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease,Zhejiang University |
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| 基金项目： | supported by grants from the National Natural Science Foundation of China (31311120063,81470096,31570026,31471253);the Ministry of Education and Science of the Russian Federation (Chinese-Russian project:RFMEFI61315X0045);the intramural special grant for influenza virus research from the Chinese Academy of Sciences (KJZD-EW-L09);the IDRCAPEIR program (106915-001);Special Project of Ministry of Science and Technology (2013FY113500);supported by the “Taishan Scholar” project of Shandong Province |
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| 摘 要： | A novel Clade 2.3.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to 2015.Based on the genetic and phylogenetic analyses,the viruses possess a stable gene constellation with a Clade 2.3.2.1c HA,a H9N2-derived PB2 gene and the other six genes of Asian H5N1-origin.The Clade 2.3.2.1c H5N1 reassortants displayed a high genetic relationship to a human H5N1 strain(A/Alberta/01/2014).Further analysis showed that similar viruses have been circulating in wild birds in China,Russia,Dubai(Western Asia),Bulgaria and Romania(Europe),as well as domestic poultry in some regions of Africa.The affected areas include the Central Asian,East Asian-Australasian,West Asian-East African,and Black Sea/Mediterranean flyways.These results show that the novel Clade 2.3.2.1c reassortant viruses are circulating worldwide and may have gained a selective advantage in migratory birds,thus posing a serious threat to wild birds and potentially humans.
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| 关 键 词： | H5N1 highly pathogenic avian influenza virus Clade 2.3.2.1c outbreak migratory birds |
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