Succinate accumulation in man during exercise |
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Authors: | Peter W Hochachka and Rudolph H Dressendorfer |
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Institution: | (1) School of Integrative Biology, The University of Queensland, 4072 Brisbane, QLD, Australia;(2) Queensland Parks and Wildlife Service, P.O. Box 155, 4002 Brisbane, QLD, Australia |
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Abstract: | It has been demonstrated in several diving vertebrates that succinate, a component of the Krebs cycle, accumulates in blood during breath-hold dives. The production of succinate is thought to result from amino acid catabolism. Our purpose was to determine whether succinate accumulation occurs in man during muscular activity requiring anaerobic energy contribution. Experiments using an endurance athlete included apneic work on an underwater ergometer and treadmill running to exhaustion. During 1 min breath-hold (V)\dot]\dot V
O2max, venous succinate increased from 42 (V)\dot]\dot V
O2max and increased succinate from a similar resting value to 93 M×10–6. Increases in alanine, lactate, and pyruvate were observed for both types of exercise. The findings confirm that succinate accumulation also occurs in man. It was suggested that amino acid catabolism may provide a source of anaerobic energy production in addition to glycolysis. However, the importance of the proposed energy pathway remains to be quantified. |
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