Mathematical Model of Leukemic-Cell Circulation in the Mouse |
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| Authors: | Marek Kimmel Barbara Kimmel Janusz Skierski |
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| Affiliation: | Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021 USA;Institute of Automation, Silesian Technical University, 44-100 Gliwice, Pstrowskiego 16, Poland;Department of Biophysics and Biomathematics, Medical Center of Postgraduate Education, Warszawa, Marymoncka 99, Poland |
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| Abstract: | L1210 leukemic cells injected in vivo are eliminated from the blood and disintegrated in organs such as the lungs and liver. We present a compartmental model which reproduces one type of in vivo experiment, based on the so-called perfusion curves. Although the data are not complete and some are only approximated, modeling gives a consistent picture of the process. |
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