The ter primordial germ cell deficiency mutation maps near Grl-1 on mouse Chromosome 18 |
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| Authors: | T Sakurai H Katoh K Moriwaki T Noguchi M Noguchi |
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| Institution: | (1) Department of Biology, Faculty of Science, Shizuoka University, Ohya 836, 422 Shizuoka, Japan;(2) Department of Genetics, Central Institute for Experimental Animals, 216 Kawasaki, Japan;(3) Department of Cell Genetics, National Institute of Genetics, 411 Mishima, Japan;(4) Genetic Stock Center, National Institute of Genetics, 411 Mishima, Japan;(5) Present address: Graduate School of Integrated Science, Yokohama City University, 236 Yokohama, Japan |
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| Abstract: | A single recessive gene, ter (teratoma), causes germ cell deficiency and a high incidence of congenital testicular teratomas in the 129/Sv-ter strain of the mouse. Linkage analyses between the ter gene and 36 marker genes of 19 chromosomes were performed with matings between the C57BL/6J-ter congenic strain and four inbred strains. Results showed that the ter gene was linked to D18Mit9, D18Mit14, and D18Mit17 on Chromosome (Chr) 18. Gene order estimated on the basis of recombination distance (in centimorgans) was centromere-D18Mit14-5.1 (cM)-ter-0 (cM)-D18Mit17-23.8 (cM)-D18Mit9]. D18Mit17 is the microsatellite DNA of the Grl-1 (glucocorticoid receptor-1) locus. We conclude that the ter gene is closely linked to Grl-1 on Chr 18 and is a new mutation involving the developmental modification of primordial germ cells in mice.Deceased |
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