Changes in hypothalamic noradrenergic systems during the anorexia of zinc deficiency |
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Authors: | Edward J Kasarskis D L Sparks John T Slevin |
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Institution: | (1) Institute of Molecular Biology and Biochemistry, Free University of Berlin, Arnimallee 22, D-1000 Berlin 33, FRG;(2) Institute of Toxicology and Prenatal Pharmacology, Free University of Berlin, Garystr. 5, D-1000 Berlin 33, FRG |
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Abstract: | Pregnant Wistar rats fed control and Zn-deficient diets received daily oral doses of 0, 100, and 300 mg/kg sodium valproate
from d 16 to 20 of gestation. Only the highest valproate doses induced a small reduction in fetal body weight in the normally
fed group. Zinc deficiency caused a drastic reduction in maternal and only a small reduction in fetal serum Zn concentrations.
Valproate treatment had no effect on maternal and fetal serum Zn concentrations.
Valproate reduced fetal liver Zn content only in the normally fed group. The reduction of liver Zn content resulted from the
reduction of Zn-metallothionein. Valproate did not affect total Zn and Zn-metallothionein in kidneys. Three percent of the
Zn-deficient fetuses developed hydronephrosis and hydrops. Valproate treatment drastically enhanced the occurrence of fetal
hydronephrosis and hydrops. Valproate induced fetal liver necroses, independent of Zn nutrition. |
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Keywords: | Zn-metallothionein effect of valproate and Zn deficiency on hydronephrosis induction by Zn deficiency and valproate hydrops induction by Zn deficiency and valproate fetal liver fetal kidney |
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