Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 (1), and the discovery of posaconazole [Sch 56592; 2 or (S,S)-5 |
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| Authors: | Bennett Frank Saksena Anil K Lovey Raymond G Liu Yi-Tsung Patel Naginbhai M Pinto Patrick Pike Russel Jao Edwin Girijavallabhan Viyyoor M Ganguly Ashit K Loebenberg David Wang Haiyan Cacciapuoti Anthony Moss Eugene Menzel Fred Hare Roberta S Nomeir Amin |
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| Institution: | Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. frank.bennett@spcorp.com |
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| Abstract: | As part of a detailed study, the syntheses, biological activities, and pharmacokinetic properties of hydroxylated analogues of the previously described broad spectrum antifungal agents, Sch 51048 (1), Sch 50001 (3), and Sch 50002 (4), are described. Based on an overall superior profile, one of the alcohols, Sch 56592 (2), was selected for clinical studies. |
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