Insertional mutation of 'classical' and novel genes in transgenic mice. |
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Authors: | M H Meisler |
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Institution: | Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109-0618. |
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Abstract: | Approximately 5% of established transgenic lines carry insertional mutations. The mutated genes may be directly isolated using the transgene DNA as a molecular probe. These mutants provide useful models of human inherited disorders and developmental abnormalities. |
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