Stimulation of sugar transport in rat diaphragm by 8-bromoguanosine 3′,5′-monophosphate |
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Authors: | M.Olivia Pinkett Robert L. Perlman |
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Affiliation: | Department of Physiology, Harvard Medical School, Boston, Mass. 02115 U.S.A. |
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Abstract: | The cyclic GMP derivative, 8-bromo cyclic GMP, increases the uptake of D-xylose and of 2-deoxy D-glucose into intact rat diaphragm incubated in vitro. 8-Bromo cyclic GMP does not stimulate the incorporation of [14C] glucose into glycogen in the diaphragm, or the uptake of α-amino isobutyric acid into this tissue. The effect of 8-bromo cyclic GMP on the diaphragm is consistent with the hypothesis that cyclic GMP plays a role in the regulation of sugar transport in muscle. |
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Keywords: | dibutyryl cyclic AMP 5′-monophosphate AIB α-aminoisobutyric acid |
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