Pyrazolo[4,3-d]pyrimidines as new generation of cyclin-dependent kinase inhibitors |
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| Authors: | Moravcová Daniela Krystof Vladimír Havlícek Libor Moravec Jirí Lenobel René Strnad Miroslav |
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| Affiliation: | Isotope Laboratory, Institute of Experimental Botany, Academy of Sciences of the Czech Republic, Vídenská 1083, 14220 Prague 4, Czech Republic. |
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| Abstract: | A search among analogues of anti-CDK purines led to the identification of substituted pyrazolo[4,3-d]pyrimidines as novel inhibitors of CDK1/cyclin B. Some of these derivatives also show antiproliferative activity on cancer cell line K-562, thus may find an application as anticancer agents. |
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