Synthesis and biological evaluation of gemcitabine-lipid conjugate (NEO6002) |
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| Authors: | Ali Shoukath M Khan Abdul R Ahmad Moghis U Chen Paul Sheikh Saifuddin Ahmad Imran |
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| Affiliation: | NeoPharm Inc., Research and Development Facility, 1850 Lakeside Drive, Waukegan, IL 60085, USA. |
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| Abstract: | A novel gemcitabine-lipid conjugate 5 was synthesized and tested for its in vivo efficacy and toxicity. Compound 5 was tested in BxPC-3 human pancreatic tumor model in SCID mice and exhibited promising activity and lower toxicity when compared with Gemzar. |
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